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ResearchIn-Press PreviewHepatologyMetabolismMicrobiology
Open Access | 
10.1172/JCI184653
Panose prevents acute-on-chronic liver failure by reducing bacterial infection in mice
Jiaxin Li,1 Shihao Xie,1 Meiling Chen,1 Changze Hong,2 Yuqi Chen,1 Fengyuan Lyu,1 Niexin Tang,1 Tianqi Chen,1 Lingyan Zhao,1 Weihao Zou,3 Hongjuan Peng,3 Jingna Bao,4 Peng Gu,1 Bernd Schnabl,5 Jinjun Chen,2 and Peng Chen1
1Department of Pathophysiology, Southern Medical University, Guangzhou, China
2Department of Infectious Diseases, Southern Medical University, Guangzhou, China
3Department of Pathogen Biology, Southern Medical University, Guangzhou, China
4Department of Critical Care Medicine, Southern Medical University, Guangzhou, China
5Department of Medicine, University of California San Diego, La Jolla, United States of America
Find articles by Li, J. in: PubMed | Google Scholar
1Department of Pathophysiology, Southern Medical University, Guangzhou, China
2Department of Infectious Diseases, Southern Medical University, Guangzhou, China
3Department of Pathogen Biology, Southern Medical University, Guangzhou, China
4Department of Critical Care Medicine, Southern Medical University, Guangzhou, China
5Department of Medicine, University of California San Diego, La Jolla, United States of America
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1Department of Pathophysiology, Southern Medical University, Guangzhou, China
2Department of Infectious Diseases, Southern Medical University, Guangzhou, China
3Department of Pathogen Biology, Southern Medical University, Guangzhou, China
4Department of Critical Care Medicine, Southern Medical University, Guangzhou, China
5Department of Medicine, University of California San Diego, La Jolla, United States of America
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1Department of Pathophysiology, Southern Medical University, Guangzhou, China
2Department of Infectious Diseases, Southern Medical University, Guangzhou, China
3Department of Pathogen Biology, Southern Medical University, Guangzhou, China
4Department of Critical Care Medicine, Southern Medical University, Guangzhou, China
5Department of Medicine, University of California San Diego, La Jolla, United States of America
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1Department of Pathophysiology, Southern Medical University, Guangzhou, China
2Department of Infectious Diseases, Southern Medical University, Guangzhou, China
3Department of Pathogen Biology, Southern Medical University, Guangzhou, China
4Department of Critical Care Medicine, Southern Medical University, Guangzhou, China
5Department of Medicine, University of California San Diego, La Jolla, United States of America
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1Department of Pathophysiology, Southern Medical University, Guangzhou, China
2Department of Infectious Diseases, Southern Medical University, Guangzhou, China
3Department of Pathogen Biology, Southern Medical University, Guangzhou, China
4Department of Critical Care Medicine, Southern Medical University, Guangzhou, China
5Department of Medicine, University of California San Diego, La Jolla, United States of America
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1Department of Pathophysiology, Southern Medical University, Guangzhou, China
2Department of Infectious Diseases, Southern Medical University, Guangzhou, China
3Department of Pathogen Biology, Southern Medical University, Guangzhou, China
4Department of Critical Care Medicine, Southern Medical University, Guangzhou, China
5Department of Medicine, University of California San Diego, La Jolla, United States of America
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1Department of Pathophysiology, Southern Medical University, Guangzhou, China
2Department of Infectious Diseases, Southern Medical University, Guangzhou, China
3Department of Pathogen Biology, Southern Medical University, Guangzhou, China
4Department of Critical Care Medicine, Southern Medical University, Guangzhou, China
5Department of Medicine, University of California San Diego, La Jolla, United States of America
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1Department of Pathophysiology, Southern Medical University, Guangzhou, China
2Department of Infectious Diseases, Southern Medical University, Guangzhou, China
3Department of Pathogen Biology, Southern Medical University, Guangzhou, China
4Department of Critical Care Medicine, Southern Medical University, Guangzhou, China
5Department of Medicine, University of California San Diego, La Jolla, United States of America
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1Department of Pathophysiology, Southern Medical University, Guangzhou, China
2Department of Infectious Diseases, Southern Medical University, Guangzhou, China
3Department of Pathogen Biology, Southern Medical University, Guangzhou, China
4Department of Critical Care Medicine, Southern Medical University, Guangzhou, China
5Department of Medicine, University of California San Diego, La Jolla, United States of America
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1Department of Pathophysiology, Southern Medical University, Guangzhou, China
2Department of Infectious Diseases, Southern Medical University, Guangzhou, China
3Department of Pathogen Biology, Southern Medical University, Guangzhou, China
4Department of Critical Care Medicine, Southern Medical University, Guangzhou, China
5Department of Medicine, University of California San Diego, La Jolla, United States of America
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1Department of Pathophysiology, Southern Medical University, Guangzhou, China
2Department of Infectious Diseases, Southern Medical University, Guangzhou, China
3Department of Pathogen Biology, Southern Medical University, Guangzhou, China
4Department of Critical Care Medicine, Southern Medical University, Guangzhou, China
5Department of Medicine, University of California San Diego, La Jolla, United States of America
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1Department of Pathophysiology, Southern Medical University, Guangzhou, China
2Department of Infectious Diseases, Southern Medical University, Guangzhou, China
3Department of Pathogen Biology, Southern Medical University, Guangzhou, China
4Department of Critical Care Medicine, Southern Medical University, Guangzhou, China
5Department of Medicine, University of California San Diego, La Jolla, United States of America
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1Department of Pathophysiology, Southern Medical University, Guangzhou, China
2Department of Infectious Diseases, Southern Medical University, Guangzhou, China
3Department of Pathogen Biology, Southern Medical University, Guangzhou, China
4Department of Critical Care Medicine, Southern Medical University, Guangzhou, China
5Department of Medicine, University of California San Diego, La Jolla, United States of America
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1Department of Pathophysiology, Southern Medical University, Guangzhou, China
2Department of Infectious Diseases, Southern Medical University, Guangzhou, China
3Department of Pathogen Biology, Southern Medical University, Guangzhou, China
4Department of Critical Care Medicine, Southern Medical University, Guangzhou, China
5Department of Medicine, University of California San Diego, La Jolla, United States of America
Find articles by Chen, J. in: PubMed | Google Scholar
1Department of Pathophysiology, Southern Medical University, Guangzhou, China
2Department of Infectious Diseases, Southern Medical University, Guangzhou, China
3Department of Pathogen Biology, Southern Medical University, Guangzhou, China
4Department of Critical Care Medicine, Southern Medical University, Guangzhou, China
5Department of Medicine, University of California San Diego, La Jolla, United States of America
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Published June 6, 2025 - More info
Copyright © 2025, Li et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)