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Usage Information

Inducible costimulator is essential for collagen-induced arthritis
Roza I. Nurieva, … , Richard A. Flavell, Chen Dong
Roza I. Nurieva, … , Richard A. Flavell, Chen Dong
Published March 1, 2003
Citation Information: J Clin Invest. 2003;111(5):701-706. https://doi.org/10.1172/JCI17321.
View: Text | PDF | Retraction
Article Autoimmunity

Inducible costimulator is essential for collagen-induced arthritis

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Abstract

CD4+ helper Th cells play a major role in the pathogenesis of rheumatoid arthritis. Th cell activation, differentiation, and immune function are regulated by costimulatory molecules. Inducible costimulator (ICOS) is a novel costimulatory receptor expressed on activated T cells. We, as well as others, recently demonstrated its importance in Th2 cytokine expression and Ab class switching by B cells. In this study, we examined the role of ICOS in rheumatoid arthritis using a collagen-induced arthritis model. We found that ICOS knockout mice on the DBA/1 background were completely resistant to collagen-induced arthritis and exhibited absence of joint tissue inflammation. These mice, when immunized with collagen, exhibited reduced anti-collagen IgM Ab’s in the initial stage and IgG2a Ab’s at the effector phase of collagen-induced arthritis. Furthermore, ICOS regulates the in vitro and in vivo expression of IL-17, a proinflammatory cytokine implicated in rheumatoid arthritis. These data indicate that ICOS is essential for collagen-induced arthritis and may suggest novel means for treating patients with rheumatoid arthritis.

Authors

Roza I. Nurieva, Piper Treuting, Julie Duong, Richard A. Flavell, Chen Dong

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Usage data is cumulative from July 2024 through July 2025.

Usage JCI PMC
Text version 947 34
PDF 190 0
Figure 300 4
Citation downloads 96 0
Totals 1,533 38
Total Views 1,571
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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