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Corrigendum Open Access | 10.1172/JCI169500

IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury

Shiqin Xiong, Zhigang Hong, Long Shuang Huang, Yoshikazu Tsukasaki, Saroj Nepal, Anke Di, Ming Zhong, Wei Wu, Zhiming Ye, Xiaopei Gao, Gadiparthi N. Rao, Dolly Mehta, Jalees Rehman, and Asrar B. Malik

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Published March 1, 2023 - More info

Published in Volume 133, Issue 5 on March 1, 2023
J Clin Invest. 2023;133(5):e169500. https://doi.org/10.1172/JCI169500.
© 2023 Xiong et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Published March 1, 2023 - Version history
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Related article:

IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury
Shiqin Xiong, … , Jalees Rehman, Asrar B. Malik
Shiqin Xiong, … , Jalees Rehman, Asrar B. Malik
Research Article Inflammation Vascular biology

IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury

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Abstract

Unchecked inflammation is a hallmark of inflammatory tissue injury in diseases such as acute respiratory distress syndrome (ARDS). Yet the mechanisms of inflammatory lung injury remain largely unknown. Here we showed that bacterial endotoxin lipopolysaccharide (LPS) and cecal ligation and puncture–induced (CLP-induced) polymicrobial sepsis decreased the expression of transcription factor cAMP response element binding (CREB) in lung endothelial cells. We demonstrated that endothelial CREB was crucial for VE-cadherin transcription and the formation of the normal restrictive endothelial adherens junctions. The inflammatory cytokine IL-1β reduced cAMP generation and CREB-mediated transcription of VE-cadherin. Furthermore, endothelial cell–specific deletion of CREB induced lung vascular injury whereas ectopic expression of CREB in the endothelium prevented the injury. We also observed that rolipram, which inhibits type 4 cyclic nucleotide phosphodiesterase–mediated (PDE4-mediated) hydrolysis of cAMP, prevented endotoxemia-induced lung vascular injury since it preserved CREB-mediated VE-cadherin expression. These data demonstrate the fundamental role of the endothelial cAMP-CREB axis in promoting lung vascular integrity and suppressing inflammatory injury. Therefore, strategies aimed at enhancing endothelial CREB-mediated VE-cadherin transcription are potentially useful in preventing sepsis-induced lung vascular injury in ARDS.

Authors

Shiqin Xiong, Zhigang Hong, Long Shuang Huang, Yoshikazu Tsukasaki, Saroj Nepal, Anke Di, Ming Zhong, Wei Wu, Zhiming Ye, Xiaopei Gao, Gadiparthi N. Rao, Dolly Mehta, Jalees Rehman, Asrar B. Malik

×

Original citation: J Clin Invest. 2020;130(7):3684–3698. https://doi.org/10.1172/JCI136908

Citation for this corrigendum: J Clin Invest. 2023;133(5):e169500. https://doi.org/10.1172/JCI169500

In the original version of Figure 4D, the representative lung histology sections of control and LPS-exposed animals, specifically the Rolipram (5 mg/kg)/PBS, Rolipram (5 mg/kg)/LPS, Rolipram (10 mg/kg)/PBS, and Rolipram (10 mg/kg)/LPS samples, inadvertently showed overlapping images from the same slide due to an error in figure assembly. The correct figure is shown below.

The authors regret the error.

Footnotes

See the related article at IL-1β Suppression of VE-cadherin Transcription Underlies Sepsis-Induced Inflammatory Lung Injury.

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  • Version 1 (March 1, 2023): Electronic publication

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