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ResearchIn-Press PreviewCardiologyStem cells
Open Access | 
10.1172/JCI164660
1-Deoxynojirimycin promotes cardiac function and rescues mitochondrial cristae in mitochondrial hypertrophic cardiomyopathy
Qianqian Zhuang,1 Fengfeng Guo,2 Lei Fu,3 Yufei Dong,3 Shaofang Xie,4 Xue Ding,1 Shuangyi Hu,3 Xuanhao D. Zhou,3 Yangwei Jiang,3 Hui Zhou,1 Yue Qiu,3 Zhaoying Lei,1 Mengyao Li,1 Huajian Cai,3 Mingjie Fan,1 Lingjie Sang,1 Yong Fu,5 Dong Zhang,1 Aifu Lin,1 Xu Li,4 Tilo Kunath,6 Ruhong Zhou,1 Ping Liang,7 Zhong Liu,2 and Qingfeng Yan1
1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
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Zhuang, Q.
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1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
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1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
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1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
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1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
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1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
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1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
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1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
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Zhou, X.
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1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
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Jiang, Y.
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1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
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1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
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1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
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1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
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1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
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1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
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1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
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Sang, L.
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1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
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1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
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Zhang, D.
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1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
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1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
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Li, X.
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1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
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Kunath, T.
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1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
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Zhou, R.
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1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
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Liang, P.
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1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
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1College of Life Sciences, Zhejiang University, Hangzhou, China
2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3College of Life Science, Zhejiang University, Hangzhou, China
4Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China
5The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
7Institute of Translational Medicine, Zhejiang University, Hangzhou, China
Find articles by Yan, Q. in: JCI | PubMed | Google Scholar
Published May 18, 2023 - More info
Copyright © 2023, Zhuang et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2023 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)