The potential role of metabolic enzyme trafficking in ROM release is illustrated. Conditions associated with resting (a), activated (b), and pregnancy (c) neutrophils are shown. ROMs are produced during all of these conditions, but ROM production is maximal for activated cells from nonpregnant women. Hexokinase and G-6-PDase have peripheral distributions in activated cells from nonpregnant women, thus allowing maximal cooperation in ROM release. m.t., microtubule; m.f., microfilament.