Advertisement
ResearchIn-Press PreviewAIDS/HIVImmunology
Open Access | 10.1172/JCI148826
1Department of Pathology, University of Cape Town, Cape Town, South Africa
2Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, United States of America
3School of Medicine, University of Washington, Seattle, United States of America
4Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, United States of America
5Department of Pediatrics, University of Washington and Seattle Children's Research Institute, Seattle, United States of America
Find articles by
Balle, C.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Pathology, University of Cape Town, Cape Town, South Africa
2Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, United States of America
3School of Medicine, University of Washington, Seattle, United States of America
4Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, United States of America
5Department of Pediatrics, University of Washington and Seattle Children's Research Institute, Seattle, United States of America
Find articles by
Armistead, B.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Pathology, University of Cape Town, Cape Town, South Africa
2Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, United States of America
3School of Medicine, University of Washington, Seattle, United States of America
4Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, United States of America
5Department of Pediatrics, University of Washington and Seattle Children's Research Institute, Seattle, United States of America
Find articles by
Kiravu, A.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Pathology, University of Cape Town, Cape Town, South Africa
2Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, United States of America
3School of Medicine, University of Washington, Seattle, United States of America
4Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, United States of America
5Department of Pediatrics, University of Washington and Seattle Children's Research Institute, Seattle, United States of America
Find articles by Song, X. in: JCI | PubMed | Google Scholar
1Department of Pathology, University of Cape Town, Cape Town, South Africa
2Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, United States of America
3School of Medicine, University of Washington, Seattle, United States of America
4Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, United States of America
5Department of Pediatrics, University of Washington and Seattle Children's Research Institute, Seattle, United States of America
Find articles by Happel, A. in: JCI | PubMed | Google Scholar
1Department of Pathology, University of Cape Town, Cape Town, South Africa
2Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, United States of America
3School of Medicine, University of Washington, Seattle, United States of America
4Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, United States of America
5Department of Pediatrics, University of Washington and Seattle Children's Research Institute, Seattle, United States of America
Find articles by Hoffmann, A. in: JCI | PubMed | Google Scholar
1Department of Pathology, University of Cape Town, Cape Town, South Africa
2Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, United States of America
3School of Medicine, University of Washington, Seattle, United States of America
4Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, United States of America
5Department of Pediatrics, University of Washington and Seattle Children's Research Institute, Seattle, United States of America
Find articles by Kanaan, S. in: JCI | PubMed | Google Scholar
1Department of Pathology, University of Cape Town, Cape Town, South Africa
2Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, United States of America
3School of Medicine, University of Washington, Seattle, United States of America
4Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, United States of America
5Department of Pediatrics, University of Washington and Seattle Children's Research Institute, Seattle, United States of America
Find articles by Nelson, J. in: JCI | PubMed | Google Scholar
1Department of Pathology, University of Cape Town, Cape Town, South Africa
2Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, United States of America
3School of Medicine, University of Washington, Seattle, United States of America
4Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, United States of America
5Department of Pediatrics, University of Washington and Seattle Children's Research Institute, Seattle, United States of America
Find articles by
Gray, C.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Pathology, University of Cape Town, Cape Town, South Africa
2Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, United States of America
3School of Medicine, University of Washington, Seattle, United States of America
4Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, United States of America
5Department of Pediatrics, University of Washington and Seattle Children's Research Institute, Seattle, United States of America
Find articles by Jaspan, H. in: JCI | PubMed | Google Scholar
1Department of Pathology, University of Cape Town, Cape Town, South Africa
2Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, United States of America
3School of Medicine, University of Washington, Seattle, United States of America
4Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, United States of America
5Department of Pediatrics, University of Washington and Seattle Children's Research Institute, Seattle, United States of America
Find articles by
Harrington, W.
in:
JCI
|
PubMed
|
Google Scholar
|
Published May 12, 2022 - More info
Determinants of the acquisition and maintenance of maternal microchimerism (MMc) during infancy and the impact of MMc on infant immune responses are unknown. We examined factors which influence MMc detection and level across infancy and the effect of MMc on T cell responses to BCG vaccination in a cohort of HIV exposed, uninfected and HIV unexposed infants in South Africa. MMc was measured in whole blood from 58 infants using a panel of quantitative PCR assays at day one and 7, 15, and 36 weeks of life. Infants received BCG at birth, and selected whole blood samples from infancy were stimulated in vitro with BCG and assessed for polyfunctional CD4+ T cell responses. MMc was present in most infants across infancy with levels ranging from 0-1,193/100,000 genomic equivalents and was positively impacted by absence of maternal HIV, maternal-infant HLA compatibility, infant female sex, and exclusive breastfeeding. Initiation of maternal antiretroviral therapy prior to pregnancy partially restored MMc levels in HIV exposed, uninfected infants. Birth MMc was associated with an improved polyfunctional CD4+ T cell response to BCG. These data emphasize that both maternal and infant factors influence MMc, which may subsequently impact infant T cell responses.