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ResearchIn-Press PreviewImmunologyOncology Free access | 10.1172/JCI142823
1Department of Immunology, University of Connecticut School of Medicine, Farmington, United States of America
2Computer Science and Engineering, Smith College, Northampton, United States of America
3Department of Chemistry and Biochemistry and Harper Cancer Research Institu, University of Notre Dame, Notre Dame, United States of America
4Proteomics and Metabolomics Facility, University of Connecticut, Storrs, United States of America
5Department of Chemistry & Biochemistry, Notre Dame, Notre Dame, United States of America
6Immunology Program, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Department of Computer Science and Engineering, University of Connecticut, Storrs, United States of America
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1Department of Immunology, University of Connecticut School of Medicine, Farmington, United States of America
2Computer Science and Engineering, Smith College, Northampton, United States of America
3Department of Chemistry and Biochemistry and Harper Cancer Research Institu, University of Notre Dame, Notre Dame, United States of America
4Proteomics and Metabolomics Facility, University of Connecticut, Storrs, United States of America
5Department of Chemistry & Biochemistry, Notre Dame, Notre Dame, United States of America
6Immunology Program, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Department of Computer Science and Engineering, University of Connecticut, Storrs, United States of America
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1Department of Immunology, University of Connecticut School of Medicine, Farmington, United States of America
2Computer Science and Engineering, Smith College, Northampton, United States of America
3Department of Chemistry and Biochemistry and Harper Cancer Research Institu, University of Notre Dame, Notre Dame, United States of America
4Proteomics and Metabolomics Facility, University of Connecticut, Storrs, United States of America
5Department of Chemistry & Biochemistry, Notre Dame, Notre Dame, United States of America
6Immunology Program, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Department of Computer Science and Engineering, University of Connecticut, Storrs, United States of America
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1Department of Immunology, University of Connecticut School of Medicine, Farmington, United States of America
2Computer Science and Engineering, Smith College, Northampton, United States of America
3Department of Chemistry and Biochemistry and Harper Cancer Research Institu, University of Notre Dame, Notre Dame, United States of America
4Proteomics and Metabolomics Facility, University of Connecticut, Storrs, United States of America
5Department of Chemistry & Biochemistry, Notre Dame, Notre Dame, United States of America
6Immunology Program, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Department of Computer Science and Engineering, University of Connecticut, Storrs, United States of America
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1Department of Immunology, University of Connecticut School of Medicine, Farmington, United States of America
2Computer Science and Engineering, Smith College, Northampton, United States of America
3Department of Chemistry and Biochemistry and Harper Cancer Research Institu, University of Notre Dame, Notre Dame, United States of America
4Proteomics and Metabolomics Facility, University of Connecticut, Storrs, United States of America
5Department of Chemistry & Biochemistry, Notre Dame, Notre Dame, United States of America
6Immunology Program, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Department of Computer Science and Engineering, University of Connecticut, Storrs, United States of America
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Al Seesi, S.
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1Department of Immunology, University of Connecticut School of Medicine, Farmington, United States of America
2Computer Science and Engineering, Smith College, Northampton, United States of America
3Department of Chemistry and Biochemistry and Harper Cancer Research Institu, University of Notre Dame, Notre Dame, United States of America
4Proteomics and Metabolomics Facility, University of Connecticut, Storrs, United States of America
5Department of Chemistry & Biochemistry, Notre Dame, Notre Dame, United States of America
6Immunology Program, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Department of Computer Science and Engineering, University of Connecticut, Storrs, United States of America
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1Department of Immunology, University of Connecticut School of Medicine, Farmington, United States of America
2Computer Science and Engineering, Smith College, Northampton, United States of America
3Department of Chemistry and Biochemistry and Harper Cancer Research Institu, University of Notre Dame, Notre Dame, United States of America
4Proteomics and Metabolomics Facility, University of Connecticut, Storrs, United States of America
5Department of Chemistry & Biochemistry, Notre Dame, Notre Dame, United States of America
6Immunology Program, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Department of Computer Science and Engineering, University of Connecticut, Storrs, United States of America
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Englander, R.
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1Department of Immunology, University of Connecticut School of Medicine, Farmington, United States of America
2Computer Science and Engineering, Smith College, Northampton, United States of America
3Department of Chemistry and Biochemistry and Harper Cancer Research Institu, University of Notre Dame, Notre Dame, United States of America
4Proteomics and Metabolomics Facility, University of Connecticut, Storrs, United States of America
5Department of Chemistry & Biochemistry, Notre Dame, Notre Dame, United States of America
6Immunology Program, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Department of Computer Science and Engineering, University of Connecticut, Storrs, United States of America
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1Department of Immunology, University of Connecticut School of Medicine, Farmington, United States of America
2Computer Science and Engineering, Smith College, Northampton, United States of America
3Department of Chemistry and Biochemistry and Harper Cancer Research Institu, University of Notre Dame, Notre Dame, United States of America
4Proteomics and Metabolomics Facility, University of Connecticut, Storrs, United States of America
5Department of Chemistry & Biochemistry, Notre Dame, Notre Dame, United States of America
6Immunology Program, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Department of Computer Science and Engineering, University of Connecticut, Storrs, United States of America
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1Department of Immunology, University of Connecticut School of Medicine, Farmington, United States of America
2Computer Science and Engineering, Smith College, Northampton, United States of America
3Department of Chemistry and Biochemistry and Harper Cancer Research Institu, University of Notre Dame, Notre Dame, United States of America
4Proteomics and Metabolomics Facility, University of Connecticut, Storrs, United States of America
5Department of Chemistry & Biochemistry, Notre Dame, Notre Dame, United States of America
6Immunology Program, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Department of Computer Science and Engineering, University of Connecticut, Storrs, United States of America
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1Department of Immunology, University of Connecticut School of Medicine, Farmington, United States of America
2Computer Science and Engineering, Smith College, Northampton, United States of America
3Department of Chemistry and Biochemistry and Harper Cancer Research Institu, University of Notre Dame, Notre Dame, United States of America
4Proteomics and Metabolomics Facility, University of Connecticut, Storrs, United States of America
5Department of Chemistry & Biochemistry, Notre Dame, Notre Dame, United States of America
6Immunology Program, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Department of Computer Science and Engineering, University of Connecticut, Storrs, United States of America
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1Department of Immunology, University of Connecticut School of Medicine, Farmington, United States of America
2Computer Science and Engineering, Smith College, Northampton, United States of America
3Department of Chemistry and Biochemistry and Harper Cancer Research Institu, University of Notre Dame, Notre Dame, United States of America
4Proteomics and Metabolomics Facility, University of Connecticut, Storrs, United States of America
5Department of Chemistry & Biochemistry, Notre Dame, Notre Dame, United States of America
6Immunology Program, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Department of Computer Science and Engineering, University of Connecticut, Storrs, United States of America
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1Department of Immunology, University of Connecticut School of Medicine, Farmington, United States of America
2Computer Science and Engineering, Smith College, Northampton, United States of America
3Department of Chemistry and Biochemistry and Harper Cancer Research Institu, University of Notre Dame, Notre Dame, United States of America
4Proteomics and Metabolomics Facility, University of Connecticut, Storrs, United States of America
5Department of Chemistry & Biochemistry, Notre Dame, Notre Dame, United States of America
6Immunology Program, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Department of Computer Science and Engineering, University of Connecticut, Storrs, United States of America
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Published December 15, 2020 - More info
Identification of neoepitopes that are effective in cancer therapy is a major challenge in creating cancer vaccines. Here, using an entirely unbiased approach, we queried all possible neoepitopes in a mouse cancer model and asked which of those are effective in mediating tumor rejection, and independently, in eliciting a measurable CD8 response. This analysis uncovered a large trove of effective anticancer neoepitopes which have strikingly different properties from conventional epitopes and suggested an algorithm to predict them. It also revealed that our current methods of prediction discard the overwhelming majority of true anticancer neoepitopes. These results from a single mouse model were validated in another, antigenically distinct mouse cancer model, and are consistent with data reported in human studies. Structural modeling showed how the MHC I-presented neoepitopes have an altered conformation, higher stability, or increased exposure to T cell receptors as compared to the un-mutated counterparts. T cells elicited by the active neoepitopes identified here demonstrated a stem-like early dysfunctional phenotype associated with effective responses against viruses and tumors of transgenic mice. These abundant anticancer neoepitopes, which have not been tested in human studies thus far, can be exploited for the generation of personalized human cancer vaccines.