Uncovering the secretes of allergic inflammation
Michael Brusilovsky,1,2 Mark Rochman,1,2 Nurit P. Azouz,1,2 Lydia E. Mack,1,2 and Marc E. Rothenberg1,2
1Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
2Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Address correspondence to: Marc Rothenberg, Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, MLC 7028, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA. Phone: 513.636.7210; Email: rothenberg@cchmc.org.
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1Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
2Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Address correspondence to: Marc Rothenberg, Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, MLC 7028, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA. Phone: 513.636.7210; Email: rothenberg@cchmc.org.
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1Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
2Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Address correspondence to: Marc Rothenberg, Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, MLC 7028, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA. Phone: 513.636.7210; Email: rothenberg@cchmc.org.
Find articles by Azouz, N. in: JCI | PubMed | Google Scholar
1Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
2Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Address correspondence to: Marc Rothenberg, Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, MLC 7028, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA. Phone: 513.636.7210; Email: rothenberg@cchmc.org.
Find articles by Mack, L. in: JCI | PubMed | Google Scholar
1Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.
2Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Address correspondence to: Marc Rothenberg, Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, MLC 7028, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA. Phone: 513.636.7210; Email: rothenberg@cchmc.org.
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Rothenberg, M.
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First published June 8, 2020 - More info
J Clin Invest. 2020;130(7):3419–3421. https://doi.org/10.1172/JCI138343.
© 2020 American Society for Clinical Investigation
Allergic asthma is a chronic inflammatory lung disease associated with increased cytokine secretion. Aspects of airway inflammation are also linked to a common genetic variant that corresponds to the small GTPase, Rab27, a protein involved in vesicular trafficking in immune cells. However, the mechanisms by which Rab27 contributes to airway inflammation and cytokine release remain ambiguous. In this issue of the JCI, Okunishi et al. explored the role that the Rab27 effector, exophilin-5, has in allergic inflammation. Exophilin-5–deficient mice and asthma mouse models revealed that exophilin-5 regulates IL-33 production and the Th2 response. Notably, exophilin-5 deletion enhanced IL-33 release and pathogenic Th2 responsiveness through the mTOR pathway and altered intracellular IL-33 trafficking. This work provides insights into the molecular mechanisms that underlie inflammatory lung disease.
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