Platelet microRNAs and vascular injury
Elena V. Dolmatova and Kathy K. Griendling
Division of Cardiology, Department of Medicine, Emory University, Atlanta, Georgia, USA.
Address correspondence to: Kathy Griendling, Emory University, Division of Cardiology, Department of Medicine, 101 Woodruff Circle, 308A WMB, Atlanta, Georgia 30322, USA. Phone: 404.727.3364; Email: kgriend@emory.edu.
Find articles by Dolmatova, E. in: JCI | PubMed | Google Scholar
Division of Cardiology, Department of Medicine, Emory University, Atlanta, Georgia, USA.
Address correspondence to: Kathy Griendling, Emory University, Division of Cardiology, Department of Medicine, 101 Woodruff Circle, 308A WMB, Atlanta, Georgia 30322, USA. Phone: 404.727.3364; Email: kgriend@emory.edu.
Find articles by Griendling, K. in: JCI | PubMed | Google Scholar
First published February 18, 2019 - More info
J Clin Invest. 2019;129(3):962–964. https://doi.org/10.1172/JCI127580.
Copyright © 2019, American Society for Clinical Investigation
Vascular smooth muscle cell (VSMC) phenotype switching from a contractile state to a synthetic phenotype has been implicated in intimal remodeling during vascular injury. While multiple studies have focused on dedifferentiation of VSMCs, prevention of VSMC-mediated excessive repair remains poorly understood. In this issue of the JCI, Zeng et al. identified a mechanism by which platelet-derived microRNA-223 (miRNA-223) reverses VSMC dedifferentiation. The authors show that suppression of proliferation occurs after platelet internalization by VSMCs. Moreover, they demonstrate that miRNA-223 inhibits dedifferentiation and intimal hyperplasia in diabetic mice by decreasing PDGFRβ expression in VSMCs. Together, these results identify platelet-derived miRNA-223 as a potential therapeutic target in vascular injury.
- Purchase this article
- $10
- Purchasing this article will give you full access for the calendar year.
- Purchase Site Pass
- $25
- This will give you access to every article on the site for 24 hours.
- Online subscription
- $95
- Individual online subscriptions give you full online access for the calendar year.
- Print subscription
- $795
- Individual print subscriptions give you the print journal and full online access for the year.
- JCI This Month subscription
- $125
- JCI This Month is a 16- to 20-page overview of the articles published each month
- Subscribing to JCI This Month also gives subscribers full online access for the calendar year.
- *Price outside U.S. and Canada: $225.
Copyright © 2019 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)