[HTML][HTML] Uncontrolled diabetes mellitus has no major influence on the platelet transcriptome
TG Nührenberg, M Cederqvist, F Marini… - BioMed Research …, 2018 - hindawi.com
Background. Diabetes mellitus (DM) has been associated with increased platelet reactivity
as well as increased levels of platelet RNAs in plasma. Here, we sought to evaluate whether
the platelet transcriptome is altered in the presence of uncontrolled DM. Methods. Next-
generation sequencing (NGS) was performed on platelet RNA for 5 patients with
uncontrolled DM (HbA1c 9.0%) and 5 control patients (HbA1c 5.5%) with otherwise similar
clinical characteristics. RNA was isolated from leucocyte-depleted platelet-rich plasma …
as well as increased levels of platelet RNAs in plasma. Here, we sought to evaluate whether
the platelet transcriptome is altered in the presence of uncontrolled DM. Methods. Next-
generation sequencing (NGS) was performed on platelet RNA for 5 patients with
uncontrolled DM (HbA1c 9.0%) and 5 control patients (HbA1c 5.5%) with otherwise similar
clinical characteristics. RNA was isolated from leucocyte-depleted platelet-rich plasma …
[PDF][PDF] Research Article Uncontrolled Diabetes Mellitus Has No Major Influence on the Platelet Transcriptome
TG Nührenberg, M Cederqvist, F Marini, C Stratz… - 2018 - academia.edu
Background. Diabetes mellitus (DM) has been associated with increased platelet reactivity
as well as increased levels of platelet RNAs in plasma. Here, we sought to evaluate whether
the platelet transcriptome is altered in the presence of uncontrolled DM. Methods. Next-
generation sequencing (NGS) was performed on platelet RNA for 5 patients with
uncontrolled DM (HbA1c 9.0%) and 5 control patients (HbA1c 5.5%) with otherwise similar
clinical characteristics. RNA was isolated from leucocyte-depleted platelet-rich plasma …
as well as increased levels of platelet RNAs in plasma. Here, we sought to evaluate whether
the platelet transcriptome is altered in the presence of uncontrolled DM. Methods. Next-
generation sequencing (NGS) was performed on platelet RNA for 5 patients with
uncontrolled DM (HbA1c 9.0%) and 5 control patients (HbA1c 5.5%) with otherwise similar
clinical characteristics. RNA was isolated from leucocyte-depleted platelet-rich plasma …