Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR
A Gatignol, A Buckler-White, BEN Berkhout, KT Jeang - Science, 1991 - science.org
A Gatignol, A Buckler-White, BEN Berkhout, KT Jeang
Science, 1991•science.orgHuman immunodeficiency virus type 1 (HIV-1) gene expression is activated by Tat, a virally
encoded protein. Tat trans-activation requires viral (trans-activation—responsive; TAR) RNA
sequences located in the R region of the long terminal repeat (LTR). Existing evidence
suggests that Tat probably cooperates with cellular factors that bind to TAR RNA in the
overall trans-activation process. A HeLa complementary DNA was isolated and
characterized that encodes a TAR RNA-binding protein (TRBP). TRBP activated the HIV-1 …
encoded protein. Tat trans-activation requires viral (trans-activation—responsive; TAR) RNA
sequences located in the R region of the long terminal repeat (LTR). Existing evidence
suggests that Tat probably cooperates with cellular factors that bind to TAR RNA in the
overall trans-activation process. A HeLa complementary DNA was isolated and
characterized that encodes a TAR RNA-binding protein (TRBP). TRBP activated the HIV-1 …
Human immunodeficiency virus type 1 (HIV-1) gene expression is activated by Tat, a virally encoded protein. Tat trans-activation requires viral (trans-activation—responsive; TAR) RNA sequences located in the R region of the long terminal repeat (LTR). Existing evidence suggests that Tat probably cooperates with cellular factors that bind to TAR RNA in the overall trans-activation process. A HeLa complementary DNA was isolated and characterized that encodes a TAR RNA-binding protein (TRBP). TRBP activated the HIV-1 LTR and was synergistic with Tat function.
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