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Ushering in the cardiac role of Ubiquilin1
Xi Fang, … , Christa Trexler, Ju Chen
Xi Fang, … , Christa Trexler, Ju Chen
Published October 22, 2018
Citation Information: J Clin Invest. 2018;128(12):5195-5197. https://doi.org/10.1172/JCI124567.
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Commentary

Ushering in the cardiac role of Ubiquilin1

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Abstract

Protein quality control (PQC) mechanisms are essential for maintaining cardiac function, and alterations in this pathway influence multiple forms of heart disease. Since heart disease is the leading cause of death worldwide, understanding how the delicate balance between protein synthesis and degradation is regulated in the heart demands attention. The study by Hu et al. reveals that the extraproteasomal ubiquitin receptor Ubiquilin1 (Ubqln1) plays an important role in cardiac ubiquitination-proteasome coupling, particularly in response to myocardial ischemia/reperfusion injury, thereby suggesting that this may be a new avenue for therapeutics.

Authors

Xi Fang, Christa Trexler, Ju Chen

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