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Research Article Free access | 10.1172/JCI116736

Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor on human thymocytes.

H K Dadi and C M Roifman

Division of Immunology/Allergy, Hospital for Sick Children, Toronto, Ontario, Canada.

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Division of Immunology/Allergy, Hospital for Sick Children, Toronto, Ontario, Canada.

Find articles by Roifman, C. in: PubMed | Google Scholar

Published September 1, 1993 - More info

Published in Volume 92, Issue 3 on September 1, 1993
J Clin Invest. 1993;92(3):1559–1563. https://doi.org/10.1172/JCI116736.
© 1993 The American Society for Clinical Investigation
Published September 1, 1993 - Version history
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Abstract

Interleukin-7 (IL-7) is a glycoprotein that regulates lymphocyte precursor growth and differentiation. However, the exact mechanism whereby the IL-7 receptor (IL-7R) mediates these cell growth signals remains unknown. One of the earliest metabolic events linked to mitogenic responses in other growth factor receptor systems is the activation of phosphatidylinositol-3 kinase (PI-3 kinase). We demonstrate here that ligation of the IL-7R results in dose- and time-dependent increases in PI-3 kinase activity. These results suggest that PI-3 kinase is involved in signal transduction via the IL-7R in human thymocytes.

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