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Research Article Free access | 10.1172/JCI115902

Widespread long-term gene transfer to mouse skeletal muscles and heart.

L D Stratford-Perricaudet, I Makeh, M Perricaudet, and P Briand

Institut Gustave Roussy, Centre National de la Recherche Scientifique, UA 1301, Villejuif, France.

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Institut Gustave Roussy, Centre National de la Recherche Scientifique, UA 1301, Villejuif, France.

Find articles by Makeh, I. in: PubMed | Google Scholar

Institut Gustave Roussy, Centre National de la Recherche Scientifique, UA 1301, Villejuif, France.

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Institut Gustave Roussy, Centre National de la Recherche Scientifique, UA 1301, Villejuif, France.

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Published August 1, 1992 - More info

Published in Volume 90, Issue 2 on August 1, 1992
J Clin Invest. 1992;90(2):626–630. https://doi.org/10.1172/JCI115902.
© 1992 The American Society for Clinical Investigation
Published August 1, 1992 - Version history
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Abstract

Successful treatment of muscular disorders awaits an adapted gene delivery protocol. The clinically applicable technique used for hematopoietic cells which is centered around implantation of retrovirally modified cells may not prove sufficient for a reversal of phenotype when muscle diseases are concerned. We report here efficient, long-term in vivo gene transfer throughout mouse skeletal and cardiac muscles after intravenous administration of a recombinant adenovirus. This simple, direct procedure raises the possibility that muscular degenerative diseases might one day be treatable by gene therapy.

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