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Research Article Free access | 10.1172/JCI115154

Reversal of daunorubicin resistance in P388/ADR cells by itraconazole.

S Gupta, J Kim, and S Gollapudi

Division of Basic and Clinical Immunology, University of California, Irvine 92717.

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Division of Basic and Clinical Immunology, University of California, Irvine 92717.

Find articles by Kim, J. in: PubMed | Google Scholar

Division of Basic and Clinical Immunology, University of California, Irvine 92717.

Find articles by Gollapudi, S. in: PubMed | Google Scholar

Published April 1, 1991 - More info

Published in Volume 87, Issue 4 on April 1, 1991
J Clin Invest. 1991;87(4):1467–1469. https://doi.org/10.1172/JCI115154.
© 1991 The American Society for Clinical Investigation
Published April 1, 1991 - Version history
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Abstract

Itraconazole is a recently developed triazole antifungal agent that inhibits cell membrane sterol biosynthesis. Itraconazole, in a dose-dependent manner, enhanced intracellular accumulation of daunorubicin and reversed the drug resistance in murine leukemia P388/ADR cells. In addition, itraconazole corrected the altered plasma membrane potentials of P388/ADR cells. The concentrations of itraconazole that reversed drug resistance are comparable to the plasma levels achieved by therapeutic dosage used in the treatment of fungal infections. Therefore, itraconazole is a potential candidate for in vivo use to reverse multidrug resistance in cancer with added benefit of its antifungal property.

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