Kappa-chain gene rearrangement in an apparent T-lineage lymphoma.

K Ha-Kawa; J Hara; Y Keiko; A Muraguchi; N Kawamura; S Ishihara; S Doi; H Yabuuchi

doi:10.1172/JCI112733

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Published in Volume 78, Issue 6 on December 1, 1986
J Clin Invest. 1986;78(6):1439–1442. https://doi.org/10.1172/JCI112733.
© 1986 The American Society for Clinical Investigation

Published December 1, 1986 - Version history

We describe a 10-yr-old boy with T-lineage non-Hodgkin's lymphoma. He had a mediastinal mass, swollen supraclavicular lymph nodes, and pleural effusion. A supraclavicular lymph node biopsy under light microscopy showed a malignant lymphoma of diffuse lymphoblastic type. Most of the cells taken from the malignant pleural effusion expressed T cell-associated antigens such as Leu-1 and OKT 8. To confirm these antigens as T-lineage lymphoma, we examined genomic DNA from malignant cells obtained from the pleural effusion. As was expected, T cell receptor beta-chain gene rearrangements were demonstrated. However, when the immunoglobulin gene organization was analyzed, we detected rearrangements in both the heavy- and kappa-chain genes. To our knowledge, this is the first case in which kappa-chain gene rearrangement was detected in apparent T-lineage cells. These findings provide important information relating to determination of the cellular lineage of lymphoid malignancy.

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