Activation of Protein C In Vivo

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Abstract

An endothelial cell-associated cofactor that greatly enhances the rate of protein C activation by thrombin has recently been described. The observation that the cofactor binds thrombin with unusually high affinity (Kd = 0.5 nM) suggested that low level thrombin infusion into dogs might lead to the selective activation of protein C.

Authors

Philip C. Comp, Rene M. Jacocks, Gary L. Ferrell, C. T. Esmon