Transport of Apolipoproteins A-I and A-II by Human Thoracic Duct Lymph

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Abstract

The daily transport of human plasma apolipoproteins A-I and A-II, triglyceride, and total cholesterol from the thoracic duct lymph into plasma was measured in two subjects before and three subjects after renal transplantation. Lymph triglyceride transport was ∼83% of the daily ingested fat loads, whereas lymph cholesterol transport was consistently greater than the amount of daily ingested cholesterol. Lymph apolipoprotein transport significantly (P < 0.05) exceeded the predicted apolipoprotein synthesis rate by an average of 659±578 mg/d for apolipoprotein A-I and 109±59 mg/d for apolipoprotein A-II among the five subjects. It is estimated that 22-77% (apolipoprotein A-I) and 28-82% (apolipoprotein A-II) of daily total body apolipoprotein synthesis takes place in the intestine.

Authors

David W. Anderson, Ernst J. Schaefer, Thomas J. Bronzert, Frank T. Lindgren, Trudy Forte, Thomas E. Starzl, Gary D. Niblack, Loren A. Zech, H. Bryan Brewer Jr.