Control of Proximal Bicarbonate Reabsorption in Normal and Acidotic Rats

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Abstract

This free-flow micropuncture study examined the dependence of bicarbonate reabsorption in the rat superficial proximal convoluted tubule to changes in filtered bicarbonate load, and thereby the contribution of the proximal tubule to the whole kidney's response to such changes. The independent effects of extracellular fluid (ECF) volume expansion and of acidosis on proximal bicarbonate reabsorption were also examined.

Authors

Martin G. Cogan, David A. Maddox, Marjory S. Lucci, Floyd C. Rector Jr., Monika R. Mueller, Kenneth R. Wong