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Research Article Free access | 10.1172/JCI108870

Glucagon release from rat pancreatic islets. A combined morphological and functional approach.

J L Carpentier, F Malaisse-Lagae, and W A Müller

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Published November 1, 1977 - More info

Published in Volume 60, Issue 5 on November 1, 1977
J Clin Invest. 1977;60(5):1174–1182. https://doi.org/10.1172/JCI108870.
© 1977 The American Society for Clinical Investigation
Published November 1, 1977 - Version history
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Abstract

The release of glucagon induced in isolated rat islets by arginine or by calcium deprivation has been subjected to combined functional and morphological quantifications. Arginine-stimulated glucagon release was associated with a significant increase of morphological events linked to exocytosis. By contrast, the paradoxical events linked to exocytosis. By contrast, the paradoxical release of glucagon provoked by calcium deprivation, although accompanied by a significant loss of granule stores, was not associated with an increase of morphologically detectable exocytosis.

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