Canine Cyclic Neutropenia: A STEM CELL DEFECT

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Abstract

Two normal collie dogs were given 1,200 R total body irradiation followed by successful marrow grafts from their grey collie littermates with cyclic hematopoiesis. During observation periods of 97 and 41 days after grafting, both previously normal recipients showed regular cyclic fluctuations of their granulocyte and reticulocyte counts similar to those observed in their donors. These findings suggest that canine cyclic neutropenia is due to a defect in the marrow stem cell.

Authors

Paul L. Weiden, Barbra Robinett, Theodore C. Graham, John Adamson, Rainer Storb