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Concise Publication Free access | 10.1172/JCI107636

Canine Cyclic Neutropenia: A STEM CELL DEFECT

Paul L. Weiden, Barbra Robinett, Theodore C. Graham, John Adamson, and Rainer Storb

Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195

United States Public Health Service Hospital, Seattle, Washington 98114

Harborview Medical Center, Seattle, Washington 98104

Veteran's Administration Hospital, Seattle, Washington 98108

Find articles by Weiden, P. in: PubMed | Google Scholar

Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195

United States Public Health Service Hospital, Seattle, Washington 98114

Harborview Medical Center, Seattle, Washington 98104

Veteran's Administration Hospital, Seattle, Washington 98108

Find articles by Robinett, B. in: PubMed | Google Scholar

Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195

United States Public Health Service Hospital, Seattle, Washington 98114

Harborview Medical Center, Seattle, Washington 98104

Veteran's Administration Hospital, Seattle, Washington 98108

Find articles by Graham, T. in: PubMed | Google Scholar

Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195

United States Public Health Service Hospital, Seattle, Washington 98114

Harborview Medical Center, Seattle, Washington 98104

Veteran's Administration Hospital, Seattle, Washington 98108

Find articles by Adamson, J. in: PubMed | Google Scholar

Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195

United States Public Health Service Hospital, Seattle, Washington 98114

Harborview Medical Center, Seattle, Washington 98104

Veteran's Administration Hospital, Seattle, Washington 98108

Find articles by Storb, R. in: PubMed | Google Scholar

Published March 1, 1974 - More info

Published in Volume 53, Issue 3 on March 1, 1974
J Clin Invest. 1974;53(3):950–953. https://doi.org/10.1172/JCI107636.
© 1974 The American Society for Clinical Investigation
Published March 1, 1974 - Version history
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Abstract

Two normal collie dogs were given 1,200 R total body irradiation followed by successful marrow grafts from their grey collie littermates with cyclic hematopoiesis. During observation periods of 97 and 41 days after grafting, both previously normal recipients showed regular cyclic fluctuations of their granulocyte and reticulocyte counts similar to those observed in their donors. These findings suggest that canine cyclic neutropenia is due to a defect in the marrow stem cell.

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