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Usage Information

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT
Bernard M. Babior, Ruby S. Kipnes, John T. Curnutte
Bernard M. Babior, Ruby S. Kipnes, John T. Curnutte
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Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

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Abstract

As a highly reactive substance produced in biological systems by the one-electron reduction of oxygen, superoxide (O2-) seemed a likely candidate as a bactericidal agent in leukocytes. The reduction of cytochrome c, a process in which O2- may serve as an electron donor, was found to occur when the cytochrome was incubated with leukocytes. O2- was identified as the agent responsible for the leukocyte-mediated reduction of cytochrome c by the demonstration that the reaction was abolished by superoxide dismutase, an enzyme that destroys O2-, but not by boiled dismutase, albumin, or catalase.

Authors

Bernard M. Babior, Ruby S. Kipnes, John T. Curnutte

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Usage data is cumulative from June 2025 through June 2026.

Usage JCI PMC
Text version 1,014 79
PDF 250 32
Scanned page 370 10
Citation downloads 174 0
Totals 1,808 121
Total Views 1,929
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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