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The nature of the renal adaptation to chronic hypocapnia
F. John Gennari, Marc B. Goldstein, William B. Schwartz
F. John Gennari, Marc B. Goldstein, William B. Schwartz
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Research Article

The nature of the renal adaptation to chronic hypocapnia

Abstract

Metabolic balance studies were carried out in normal dogs to define the renal mechanisms responsible for the adaptation to, and recovery from, chronic hypocapnia. A chronic reduction in arterial CO2 tension (PaCO2) of some 15 mm Hg was achieved by means of chronic exposure of the animals to 9% oxygen in an environmental chamber. The development of hypocapnia was associated with a marked suppression of net acid excretion which, together with a slight accumulation of organic acids, produced a reduction in plasma bicarbonate concentration (8 mEq/liter) that led to nearly full protection of extracellular pH (ΔH+ = - 2.5 nmoles/liter). When PaCO2 was returned to control levels, an augmentation of acid excretion restored plasma composition to normal after a brief period of “posthypocapneic metabolic acidosis.”

Authors

F. John Gennari, Marc B. Goldstein, William B. Schwartz

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