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Research Article Free access | 10.1172/JCI106953

Altered membrane sodium transport in Bartter's syndrome

Jerry D. Gardner, Artemis P. Simopoulos, Allen Lapey, and Shlomo Shibolet

Digestive and Hereditary Diseases Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014

Metabolic Diseases Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014

Endocrinology Branch, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014

Find articles by Gardner, J. in: JCI | PubMed | Google Scholar

Digestive and Hereditary Diseases Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014

Metabolic Diseases Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014

Endocrinology Branch, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014

Find articles by Simopoulos, A. in: JCI | PubMed | Google Scholar

Digestive and Hereditary Diseases Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014

Metabolic Diseases Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014

Endocrinology Branch, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014

Find articles by Lapey, A. in: JCI | PubMed | Google Scholar

Digestive and Hereditary Diseases Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014

Metabolic Diseases Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014

Endocrinology Branch, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014

Find articles by Shibolet, S. in: JCI | PubMed | Google Scholar

Published June 1, 1972 - More info

Published in Volume 51, Issue 6 on June 1, 1972
J Clin Invest. 1972;51(6):1565–1571. https://doi.org/10.1172/JCI106953.
© 1972 The American Society for Clinical Investigation
Published June 1, 1972 - Version history
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Abstract

To explore the possibility that Bartter's syndrome is the manifestation of an inherited abnormality of sodium transport, we have measured various parameters of sodium transport in erythrocytes from patients with Bartter's syndrome, their siblings, and their parents. Sodium transport in six of the eight patients with Bartter's syndrome differed significantly from that in the other two patients. On the basis of this difference, the patients were divided into two groups (type I and type II). In the six type I patients, fractional sodium outflux (0.38±0.05/hr [SD]) was significantly less than normal (0.50±0.07) and erythrocyte sodium concentration (9.48±0.84 mmoles/liter cells per hr) was significantly greater than normal (5.24±0.66). In the two type II patients, none of the measured parameters of sodium transport differed significantly from normal. Erythrocyte sodium transport in the relatives of three type I patients was altered in a way similar to that in the type I patients and was significantly different from that in the relatives of a type II patient. These findings indicate the presence of inherited alterations of erythrocyte sodium transport in certain patients with Bartter's syndrome.

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Version history
  • Version 1 (June 1, 1972): No description
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