The effect of bacterial products on synovial fibroblast function: hypermetabolic changes induced by endotoxin

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Abstract

The effects of bacterial products on selected synovial fibroblast functions were studied. Extracts of commonly encountered microorganisms were prepared by sonic or mechanical disruption. “Purified” endotoxins were prepared from selected organisms, and in some cases were purchased commercially. Normal fibroblasts were derived from synovial connective tissue obtained from amputations or arthrotomy. The cells were grown as a monolayer on glass and were nourished by a semisynthetic nutrient medium.

Authors

Robert B. Buckingham, C. William Castor