Synthesis and release of proinsulin and insulin by isolated rat islets of Langerhans

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Abstract

Isolated rat islets of Langerhans were incubated for 60, 120, and 180 min and the incorporation of leucine-3H into proinsulin and insulin moieties was followed. Synthesis and release of these hormones could be followed by separate extractions of islets and incubation media.

Authors

Tomio Tanese, Norman R. Lazarus, Sevim Devrim, Lillian Recant