The effects of abnormal sympathetic nervous function upon the ventilatory response to hypoxia

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Abstract

The ventilatory response to hypoxia was studied in two groups of subjects with abnormal sympathetic nervous control: (a) human subjects with familial dysautonomia (Riley-Day syndrome), and (b) unanesthetized goats treated with an alpha-adrenergic blocking agent (phenoxybenzamine). The ventilatory response to hypoxia was evaluated in two ways: (a) from the slope of the relationship between ventilation and alveolar PCo2 ([unk]VE-PACo2 slope) during the rebreathing of hypoxic and hyperoxic gases, and (b) from the change in ventilation produced when hypoxia was abruptly relieved.

Authors

N. H. Edelman, N. S. Cherniack, S. Lahiri, E. Richards, A. P. Fishman