Mechanism of excessive purine biosynthesis in hypoxanthine-guanine phosphoribosyltransferase deficiency
Leif B. Sorensen
Leif B. Sorensen
Published May 1, 1970
Citation Information: J Clin Invest. 1970;49(5):968-978. https://doi.org/10.1172/JCI106316.
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Research Article

Mechanism of excessive purine biosynthesis in hypoxanthine-guanine phosphoribosyltransferase deficiency

Abstract

Certain gouty subjects with excessive de novo purine synthesis are deficient in hypoxanthineguanine phosphoribosyltransferase (HG-PRTase [EC 2.4.2.8]). The mechanism of accelerated uric acid formation in these patients was explored by measuring the incorporation of glycine-14C into various urinary purine bases of normal and enzyme-deficient subjects during treatment with the xanthine oxidase inhibitor, allopurinol.

Authors

Leif B. Sorensen

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Other pages:
968 969 970 971 972 973 974 975 976 977 978

Other pages:
968 969 970 971 972 973 974 975 976 977 978