Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Pancreatic Cancer (Jul 2025)
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Research Article Free access | 10.1172/JCI106157

Anaerobic performance and metabolism of the hyperthyroid heart

Ruth A. Altschuld, Alan Weiss, Fred A. Kruger, and Arnold M. Weissler

1Department of Medicine, Ohio State University College of Medicine, Columbus, Ohio 43210

Find articles by Altschuld, R. in: PubMed | Google Scholar

1Department of Medicine, Ohio State University College of Medicine, Columbus, Ohio 43210

Find articles by Weiss, A. in: PubMed | Google Scholar

1Department of Medicine, Ohio State University College of Medicine, Columbus, Ohio 43210

Find articles by Kruger, F. in: PubMed | Google Scholar

1Department of Medicine, Ohio State University College of Medicine, Columbus, Ohio 43210

Find articles by Weissler, A. in: PubMed | Google Scholar

Published October 1, 1969 - More info

Published in Volume 48, Issue 10 on October 1, 1969
J Clin Invest. 1969;48(10):1905–1913. https://doi.org/10.1172/JCI106157.
© 1969 The American Society for Clinical Investigation
Published October 1, 1969 - Version history
View PDF
Abstract

Anaerobically periused hearts from rats with experimentally induced hyperthyroidism exhibited accelerated deterioration of pacemaker activity and ventricular performance. The diminished anaerobic performance of hyperthyroid hearts was associated with decreased adenosine triphosphate (ATP) levels and a reduced rate of anaerobic glycolysis as reflected in decreased lactic acid production during 30 min of anoxic perfusion.

Studies on whole heart homogenates demonstrated inhibition at the phosphofructokinase (PFK) step of the glycolytic pathway. Such inhibition was not demonstrated in the hyperthyroid heart cytosol. It is postulated that an inhibitor of PFK which resides dominantly in the particulate fraction is probably responsible for the diminished anaerobic glycolysis and performance of the hyperthyroid heart.

Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 1905
page 1905
icon of scanned page 1906
page 1906
icon of scanned page 1907
page 1907
icon of scanned page 1908
page 1908
icon of scanned page 1909
page 1909
icon of scanned page 1910
page 1910
icon of scanned page 1911
page 1911
icon of scanned page 1912
page 1912
icon of scanned page 1913
page 1913
Version history
  • Version 1 (October 1, 1969): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts