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Anaerobic performance and metabolism of the hyperthyroid heart
Ruth A. Altschuld, … , Fred A. Kruger, Arnold M. Weissler
Ruth A. Altschuld, … , Fred A. Kruger, Arnold M. Weissler
Published October 1, 1969
Citation Information: J Clin Invest. 1969;48(10):1905-1913. https://doi.org/10.1172/JCI106157.
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Research Article

Anaerobic performance and metabolism of the hyperthyroid heart

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Abstract

Anaerobically periused hearts from rats with experimentally induced hyperthyroidism exhibited accelerated deterioration of pacemaker activity and ventricular performance. The diminished anaerobic performance of hyperthyroid hearts was associated with decreased adenosine triphosphate (ATP) levels and a reduced rate of anaerobic glycolysis as reflected in decreased lactic acid production during 30 min of anoxic perfusion.

Authors

Ruth A. Altschuld, Alan Weiss, Fred A. Kruger, Arnold M. Weissler

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