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Research Article Free access | 10.1172/JCI106052

Plasma Progesterone and 17-hydroxyprogesterone in normal men and children with congenital adrenal hyperplasia

Charles A. Strott, Teruya Yoshimi, and Mortimer B. Lipsett

1Endocrinology Branch, National Cancer Institute, Bethesda, Maryland 20014

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1Endocrinology Branch, National Cancer Institute, Bethesda, Maryland 20014

Find articles by Yoshimi, T. in: PubMed | Google Scholar

1Endocrinology Branch, National Cancer Institute, Bethesda, Maryland 20014

Find articles by Lipsett, M. in: PubMed | Google Scholar

Published May 1, 1969 - More info

Published in Volume 48, Issue 5 on May 1, 1969
J Clin Invest. 1969;48(5):930–939. https://doi.org/10.1172/JCI106052.
© 1969 The American Society for Clinical Investigation
Published May 1, 1969 - Version history
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Abstract

Plasma 17-hydroxyprogesterone (17-OHP) concentrations in normal men averaged 0.094 μg/100 ml. Studies using suppressive doses of androgens and glucocorticoids showed that 90% of the 17-OHP originated from the Leydig cell. The 17-OHP production rate was 1.8 mg/24 hr. Plasma 17-OHP has a marked circadian variation, the 8 p.m. values being only 40% of the 8 a.m. values. Plasma luteinizing hormone measured in the same samples did not vary.

The adrenal cortex has the capacity to synthesize and secrete 17-OHP and progesterone since adrenocorticotrophic hormone (ACTH) caused a fourfold increase in these plasma steroids. In children with congenital adrenal hyperplasia, plasma 17-OHP levels were 50-200 times those of normal men and plasma progesterone was increased 6- to 10-fold over normal men.

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