Inherited deficiency of the third component of human complement (C′3)

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Abstract

A kindred has been investigated in which seven individuals were found to have half-normal serum concentrations of the third component of complement (C′3). This partial deficiency was transmitted as an autosomal dominant trait. Affected individuals were entirely healthy. Hemolytic complement titers were slightly reduced but immune adherence titers and reagent titrations of the classical complement components were normal.

Authors

Chester A. Alper, Richard P. Propp, Martin R. Klemperer, Fred S. Rosen, Lillian Watson