Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Alerts
  • Advertising/recruitment
  • Subscribe
  • Contact
  • Current Issue
  • Past Issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews ...
    • 100th Anniversary of Insulin's Discovery (Jan 2021)
    • Hypoxia-inducible factors in disease pathophysiology and therapeutics (Oct 2020)
    • Latency in Infectious Disease (Jul 2020)
    • Immunotherapy in Hematological Cancers (Apr 2020)
    • Big Data's Future in Medicine (Feb 2020)
    • Mechanisms Underlying the Metabolic Syndrome (Oct 2019)
    • Reparative Immunology (Jul 2019)
    • View all review series ...
  • Viewpoint
  • Collections
    • Recently published
    • In-Press Preview
    • Commentaries
    • Concise Communication
    • Editorials
    • Viewpoint
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Author's Takes
  • Recently published
  • In-Press Preview
  • Commentaries
  • Concise Communication
  • Editorials
  • Viewpoint
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Alerts
  • Advertising/recruitment
  • Subscribe
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a letter
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need Help? E-mail the JCI
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Research Article Free access | 10.1172/JCI105650

Brain Metabolism during Fasting

O. E. Owen, A. P. Morgan, H. G. Kemp, J. M. Sullivan, M. G. Herrera, and G. F. Cahill Jr.

Elliott P. Joslin Research Laboratory, Department of Medicine, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts

Elliott P. Joslin Research Laboratory, Department of Surgery, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts

‡

Investigator, Howard Hughes Medical Institute.

Address requests for reprints to Dr. G. F. Cahill, Jr., Joslin Research Laboratory, 170 Pilgrim Road, Boston, Mass. 02215.

*

Received for publication 17 April 1967 and in revised form 23 June 1967.

This study was supported in part by grants from the U. S. Public Health Service AM-09584-02, AM-09748-02, 8 MO1-FR-31-06, T1-AM-5077-11, 5-RO1-AM-02657-07, 1-T1-HE-05679-02, and HE-08591-02; the Adler Foundation, Inc., Rye, N. Y.; the U. S. Army Medical Research and Development Command (DA-49-193-MO-2337); the John A. Hartford Foundation, Inc., New York, N. Y.; and the Atomic Energy Commission.

A preliminary abstract of part of this work has been published (1).

Find articles by Owen, O. in: JCI | PubMed | Google Scholar

Elliott P. Joslin Research Laboratory, Department of Medicine, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts

Elliott P. Joslin Research Laboratory, Department of Surgery, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts

‡

Investigator, Howard Hughes Medical Institute.

Address requests for reprints to Dr. G. F. Cahill, Jr., Joslin Research Laboratory, 170 Pilgrim Road, Boston, Mass. 02215.

*

Received for publication 17 April 1967 and in revised form 23 June 1967.

This study was supported in part by grants from the U. S. Public Health Service AM-09584-02, AM-09748-02, 8 MO1-FR-31-06, T1-AM-5077-11, 5-RO1-AM-02657-07, 1-T1-HE-05679-02, and HE-08591-02; the Adler Foundation, Inc., Rye, N. Y.; the U. S. Army Medical Research and Development Command (DA-49-193-MO-2337); the John A. Hartford Foundation, Inc., New York, N. Y.; and the Atomic Energy Commission.

A preliminary abstract of part of this work has been published (1).

Find articles by Morgan, A. in: JCI | PubMed | Google Scholar

Elliott P. Joslin Research Laboratory, Department of Medicine, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts

Elliott P. Joslin Research Laboratory, Department of Surgery, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts

‡

Investigator, Howard Hughes Medical Institute.

Address requests for reprints to Dr. G. F. Cahill, Jr., Joslin Research Laboratory, 170 Pilgrim Road, Boston, Mass. 02215.

*

Received for publication 17 April 1967 and in revised form 23 June 1967.

This study was supported in part by grants from the U. S. Public Health Service AM-09584-02, AM-09748-02, 8 MO1-FR-31-06, T1-AM-5077-11, 5-RO1-AM-02657-07, 1-T1-HE-05679-02, and HE-08591-02; the Adler Foundation, Inc., Rye, N. Y.; the U. S. Army Medical Research and Development Command (DA-49-193-MO-2337); the John A. Hartford Foundation, Inc., New York, N. Y.; and the Atomic Energy Commission.

A preliminary abstract of part of this work has been published (1).

Find articles by Kemp, H. in: JCI | PubMed | Google Scholar

Elliott P. Joslin Research Laboratory, Department of Medicine, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts

Elliott P. Joslin Research Laboratory, Department of Surgery, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts

‡

Investigator, Howard Hughes Medical Institute.

Address requests for reprints to Dr. G. F. Cahill, Jr., Joslin Research Laboratory, 170 Pilgrim Road, Boston, Mass. 02215.

*

Received for publication 17 April 1967 and in revised form 23 June 1967.

This study was supported in part by grants from the U. S. Public Health Service AM-09584-02, AM-09748-02, 8 MO1-FR-31-06, T1-AM-5077-11, 5-RO1-AM-02657-07, 1-T1-HE-05679-02, and HE-08591-02; the Adler Foundation, Inc., Rye, N. Y.; the U. S. Army Medical Research and Development Command (DA-49-193-MO-2337); the John A. Hartford Foundation, Inc., New York, N. Y.; and the Atomic Energy Commission.

A preliminary abstract of part of this work has been published (1).

Find articles by Sullivan, J. in: JCI | PubMed | Google Scholar

Elliott P. Joslin Research Laboratory, Department of Medicine, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts

Elliott P. Joslin Research Laboratory, Department of Surgery, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts

‡

Investigator, Howard Hughes Medical Institute.

Address requests for reprints to Dr. G. F. Cahill, Jr., Joslin Research Laboratory, 170 Pilgrim Road, Boston, Mass. 02215.

*

Received for publication 17 April 1967 and in revised form 23 June 1967.

This study was supported in part by grants from the U. S. Public Health Service AM-09584-02, AM-09748-02, 8 MO1-FR-31-06, T1-AM-5077-11, 5-RO1-AM-02657-07, 1-T1-HE-05679-02, and HE-08591-02; the Adler Foundation, Inc., Rye, N. Y.; the U. S. Army Medical Research and Development Command (DA-49-193-MO-2337); the John A. Hartford Foundation, Inc., New York, N. Y.; and the Atomic Energy Commission.

A preliminary abstract of part of this work has been published (1).

Find articles by Herrera, M. in: JCI | PubMed | Google Scholar

Elliott P. Joslin Research Laboratory, Department of Medicine, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts

Elliott P. Joslin Research Laboratory, Department of Surgery, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts

‡

Investigator, Howard Hughes Medical Institute.

Address requests for reprints to Dr. G. F. Cahill, Jr., Joslin Research Laboratory, 170 Pilgrim Road, Boston, Mass. 02215.

*

Received for publication 17 April 1967 and in revised form 23 June 1967.

This study was supported in part by grants from the U. S. Public Health Service AM-09584-02, AM-09748-02, 8 MO1-FR-31-06, T1-AM-5077-11, 5-RO1-AM-02657-07, 1-T1-HE-05679-02, and HE-08591-02; the Adler Foundation, Inc., Rye, N. Y.; the U. S. Army Medical Research and Development Command (DA-49-193-MO-2337); the John A. Hartford Foundation, Inc., New York, N. Y.; and the Atomic Energy Commission.

A preliminary abstract of part of this work has been published (1).

Find articles by Cahill, G. in: JCI | PubMed | Google Scholar

Published October 1, 1967 - More info

Published in Volume 46, Issue 10 on October 1, 1967
J Clin Invest. 1967;46(10):1589–1595. https://doi.org/10.1172/JCI105650.
© 1967 The American Society for Clinical Investigation
Published October 1, 1967 - Version history
View PDF
Abstract

Catheterization of cerebral vessels in three obese patients undergoing 5-6 wk of starvation demonstrated that β-hydroxybutyrate and acetoacetate replaced glucose as the predominant fuel for brain metabolism. A strikingly low respiratory quotient was also observed, suggesting a carboxylation mechanism as a means of disposing of some of the carbon of the consumed substrates.

Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 1589
page 1589
icon of scanned page 1590
page 1590
icon of scanned page 1591
page 1591
icon of scanned page 1592
page 1592
icon of scanned page 1593
page 1593
icon of scanned page 1594
page 1594
icon of scanned page 1595
page 1595
Version history
  • Version 1 (October 1, 1967): No description

Article tools

  • View PDF
  • Download citation information
  • Send a letter
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need Help? E-mail the JCI

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement
Follow JCI:
Copyright © 2021 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts