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Research Article Free access | 10.1172/JCI105567
Department of Paediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada,
The Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
†Present address: Zifkin Biological Laboratories, Toronto, Ontario, Canada.
‡Address requests for reprints to Dr. Andrew Sass-Kortsak, 555 University Avenue, Toronto, Ontario, Canada.
*Submitted for publication May 31, 1966; accepted December 30, 1966.
Supported by funds from the John A. Hartford Foundation, New York, N. Y.
Presented in part at the annual meeting of The Canadian Federation of Biological Societies, Halifax, Nova Scotia, June 1964.
Find articles by Harris, D. in: JCI | PubMed | Google Scholar
Department of Paediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada,
The Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
†Present address: Zifkin Biological Laboratories, Toronto, Ontario, Canada.
‡Address requests for reprints to Dr. Andrew Sass-Kortsak, 555 University Avenue, Toronto, Ontario, Canada.
*Submitted for publication May 31, 1966; accepted December 30, 1966.
Supported by funds from the John A. Hartford Foundation, New York, N. Y.
Presented in part at the annual meeting of The Canadian Federation of Biological Societies, Halifax, Nova Scotia, June 1964.
Find articles by Sass-Kortsak, A. in: JCI | PubMed | Google Scholar
Published April 1, 1967 - More info
Addition of physiological concentrations of 20 l-amino acids to the incubation medium facilitates the uptake of copper by liver slices. This effect can be observed in a wide range of initial concentrations of copper in the medium, including the low physiological concentrations. The uptake of copper was not influenced by the addition of sodium lactate or d-glucose to the incubation media. The facilitation of copper uptake by amino acids is abolished under anaerobic conditions. It is not affected by the presence of 2,4-dinitrophenol. The type of transport and its exact mechanism have not been established, but this type of transport does not fulfill the criteria for classification as simple diffusion.