The Influence of Amino Acids on Copper Uptake by Rat Liver Slices

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Abstract

Addition of physiological concentrations of 20 l-amino acids to the incubation medium facilitates the uptake of copper by liver slices. This effect can be observed in a wide range of initial concentrations of copper in the medium, including the low physiological concentrations. The uptake of copper was not influenced by the addition of sodium lactate or d-glucose to the incubation media. The facilitation of copper uptake by amino acids is abolished under anaerobic conditions. It is not affected by the presence of 2,4-dinitrophenol. The type of transport and its exact mechanism have not been established, but this type of transport does not fulfill the criteria for classification as simple diffusion.

Authors

Daisy I. M. Harris, Andrew Sass-Kortsak