Immunopathologic Studies of Systemic Lupus Erythematosus (SLE). I. Tissue-bound Immunoglobulins in Relation to Serum Antinuclear Immunoglobulins in Systemic Lupus and in Chronic Liver Disease with LE Cell Factor

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Abstract

We studied the composition of tissue-bound immunoglobulins and of antinuclear factors by immunofluorescent techniques in five patients with systemic lupus and two with chronic liver disease associated with positive LE cell tests. Renal glomeruli in all seven demonstrated deposits of bound γG-globulin and complement, although the presence of γA- and γM-immunoglobulins was variable. Blood vessel walls contained primarily γG-globulin and complement in the systemic lupus patients, but such deposits were absent from vessels in the two with chronic liver disease.

Authors

Kathryn H. Svec, John D. Blair, Melvin H. Kaplan