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Research Article Free access | 10.1172/JCI105557

Immunopathologic Studies of Systemic Lupus Erythematosus (SLE). I. Tissue-bound Immunoglobulins in Relation to Serum Antinuclear Immunoglobulins in Systemic Lupus and in Chronic Liver Disease with LE Cell Factor

Kathryn H. Svec, John D. Blair, and Melvin H. Kaplan

Department of Medicine, Western Reserve University School of Medicine, Cleveland, Ohio

Department of Pathology, Western Reserve University School of Medicine, Cleveland, Ohio

University Hospitals and Metropolitan General Hospital, Cleveland, Ohio

†

Research Career awardee of the U. S. Public Health Service (5-K6-HE-4576). Address requests for reprints to Dr. M. H. Kaplan, Dept. of Medicine, Metropolitan General Hospital, Cleveland, Ohio.

*

Submitted for publication February 21, 1966; accepted December 22, 1966.

Presented at the annual meeting of the American Rheumatism Association, Denver, Colo., June 17-18, 1966 (Arthr. and Rheum. 1966, 9, 546).

This work was supported by the Hankins Foundation and by research grant HE-03726 from the National Heart Institute, U. S. Public Health Service.

Find articles by Svec, K. in: PubMed | Google Scholar

Department of Medicine, Western Reserve University School of Medicine, Cleveland, Ohio

Department of Pathology, Western Reserve University School of Medicine, Cleveland, Ohio

University Hospitals and Metropolitan General Hospital, Cleveland, Ohio

†

Research Career awardee of the U. S. Public Health Service (5-K6-HE-4576). Address requests for reprints to Dr. M. H. Kaplan, Dept. of Medicine, Metropolitan General Hospital, Cleveland, Ohio.

*

Submitted for publication February 21, 1966; accepted December 22, 1966.

Presented at the annual meeting of the American Rheumatism Association, Denver, Colo., June 17-18, 1966 (Arthr. and Rheum. 1966, 9, 546).

This work was supported by the Hankins Foundation and by research grant HE-03726 from the National Heart Institute, U. S. Public Health Service.

Find articles by Blair, J. in: PubMed | Google Scholar

Department of Medicine, Western Reserve University School of Medicine, Cleveland, Ohio

Department of Pathology, Western Reserve University School of Medicine, Cleveland, Ohio

University Hospitals and Metropolitan General Hospital, Cleveland, Ohio

†

Research Career awardee of the U. S. Public Health Service (5-K6-HE-4576). Address requests for reprints to Dr. M. H. Kaplan, Dept. of Medicine, Metropolitan General Hospital, Cleveland, Ohio.

*

Submitted for publication February 21, 1966; accepted December 22, 1966.

Presented at the annual meeting of the American Rheumatism Association, Denver, Colo., June 17-18, 1966 (Arthr. and Rheum. 1966, 9, 546).

This work was supported by the Hankins Foundation and by research grant HE-03726 from the National Heart Institute, U. S. Public Health Service.

Find articles by Kaplan, M. in: PubMed | Google Scholar

Published April 1, 1967 - More info

Published in Volume 46, Issue 4 on April 1, 1967
J Clin Invest. 1967;46(4):558–568. https://doi.org/10.1172/JCI105557.
© 1967 The American Society for Clinical Investigation
Published April 1, 1967 - Version history
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Abstract

We studied the composition of tissue-bound immunoglobulins and of antinuclear factors by immunofluorescent techniques in five patients with systemic lupus and two with chronic liver disease associated with positive LE cell tests. Renal glomeruli in all seven demonstrated deposits of bound γG-globulin and complement, although the presence of γA- and γM-immunoglobulins was variable. Blood vessel walls contained primarily γG-globulin and complement in the systemic lupus patients, but such deposits were absent from vessels in the two with chronic liver disease.

We observed antinuclear factors, demonstrated by immunofluorescence, in all three immunoglobulin classes. In six of the seven patients, evidence was obtained of a correspondence between the classes of bound immunoglobulins in glomeruli and vessels and the serum titers of antinuclear immunoglobulins. These observations are consistent with the concept that immunoglobulin deposits in tissues may be derived at least in part from antinuclear factors.

Neither bound immunoglobulins nor complement was observed in liver parenchyma of the two patients with chronic liver disease or in two patients with systemic lupus and liver pathology. It thus seems doubtful that serum antibodies play a primary role in the pathogenesis of forms of chronic liver disease associated with positive LE cell tests.

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