Video abstracts

In this video collection, authors of findings published in The Journal of Clinical Investigation present personally guided tours of their results. The journal accepts video submissions from authors of recently accepted manuscripts. Instructions can be found on the Video Abstracts Guidelines page.

PSD-95 expression controls L-DOPA dyskinesia through dopamine D1 receptor trafficking

Erwan Bezard and Laurent Groc of the University of Bordeaux discuss the effects of the post-synaptic density protein PSD-95 on the development of levodopa-induced dyskinesia. Highlights:

  • L-DOPA-induced dyskinesia (LID) is a major side effect of dopamine replacement therapy for Parkinson’s disease.
  • LID is associated with changes in D1 dopamine receptor (D1R) interactions at the striatal synapses.
  • Using rat and macaque models, Bezard, Groc, and colleagues demonstrated that the synaptic density protein PSD-95 alters the trafficking of D1R to the synapse.
  • Loss of PSD-95 in the striatum reduces the development and severity of LID.
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