Isoprenoids as mediators of the biological effects of statins

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James K. Liao

The therapeutic potential of modulating the ceramide/sphingomyelin pathway

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Richard Kolesnick

Aquaporin water channels: atomic structure molecular dynamics meet clinical medicine

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David Kozono, Masato Yasui, Landon S. King, Peter Agre

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

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Jay D. Horton, Joseph L. Goldstein, Michael S. Brown

Mixed signals in heart failure: cancer rules

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Masahiko Hoshijima, Kenneth R. Chien

The challenge of target sequence specificity in C→U RNA editing

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Nicholas O. Davidson

Killing the messenger: new insights into nonsense-mediated mRNA decay

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Peter H. Byers

Caveolin-deficient mice: insights into caveolar function human disease

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Babak Razani, Michael P. Lisanti

Spotlight on BACE: The secretases as targets for treatment in Alzheimer disease

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Colin Dingwall

Challenges to achieving clinical transplantation tolerance

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Alan D. Salama, Giuseppe Remuzzi, William E. Harmon, Mohamed H. Sayegh