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Aquaporin water channels: atomic structure molecular dynamics meet clinical medicine
David Kozono, … , Landon S. King, Peter Agre
David Kozono, … , Landon S. King, Peter Agre
Published June 1, 2002
Citation Information: J Clin Invest. 2002;109(11):1395-1399. https://doi.org/10.1172/JCI15851.
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Aquaporin water channels: atomic structure molecular dynamics meet clinical medicine

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Abstract

Authors

David Kozono, Masato Yasui, Landon S. King, Peter Agre

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Figure 1

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Ribbon diagram of the structure of an AQP1 subunit (sagittal section). T...
Ribbon diagram of the structure of an AQP1 subunit (sagittal section). The model is based on Protein Data Bank coordinates 1H6I of human red cell AQP1 (8). The amino-terminus is blue and the carboxy-terminus is red. Six membrane-spanning helices surround two hemipores (loops with short helices — cyan and orange) that meet in the center of the bilayer. The white arrow illustrates the aqueous channel through the protein.
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