Ramos and colleagues demonstrate that CAR T cells engineered to target κ-light chain-expressing B cells can be infused safely and effectively in human patients with a variety of cancerous B cell malignancies…
Published June 6, 2016

Nicola M. Tomas, Elion Hoxha, and colleagues provide evidence that anti-THSD7A antibodies promote the development of membranous nephropathy...
Published May 23, 2016

Luke Bonser and colleagues characterize the composition and transport of pathogenic, asthma-associated mucus…
Published May 16, 2016

Taichiro Nonaka and colleagues find that AID plays a role in the development of inflammation-driven, non-UV skin cancer
Published March 14, 2016

Haiyang Yu, Mykyta Artomov, Sebastian Brähler and colleagues demonstrate the genetic contribution to the development of focal segmental glomerulosclerosis...
Published February 22, 2016

Charlotte de Winde, Sharon Veenbergen, and colleagues demonstrate that loss of CD37 expression relieves SOCS3-mediated suppression of IL-6 signaling and supports the development of B cell lymphoma…
Published January 19, 2016

Jian Chen and colleagues present evidence that dysfunctional TGF-β/β2SP/CTFC signaling underlies spontaneous tumor development in Beckwith-Wiedemann syndrome…
Published January 19, 2016

Rocío López-Posadas and colleagues reveal that loss of Rho-A activation and signaling promotes loss of intestinal barrier function in inflammatory bowel disease…
Published January 11, 2016

José Naranjo and colleagues reveal that downregulation of DREAM mediates derepression of ATF6, and this elevation of ATF6 plays an early neuroprotective role in Huntington’s disease…
Published January 11, 2016

Kai Hu and Bjorn Olsen reveal that osteoblast-derived VEGF serves as a proinflammatory, angiogenic, and osteogenic factor during bone healing…
Published January 5, 2016