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Research Letter

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Addiction of primary cutaneous γδ T cell lymphomas to JAK/STAT signaling
Yue Zhang, … , Naiem T. Issa, Jaehyuk Choi
Yue Zhang, … , Naiem T. Issa, Jaehyuk Choi
Published April 15, 2025
Citation Information: J Clin Invest. 2025;135(8):e180417. https://doi.org/10.1172/JCI180417.
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Addiction of primary cutaneous γδ T cell lymphomas to JAK/STAT signaling

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Abstract

Authors

Yue Zhang, Julia A. Yescas, Kristy Tefft, Spencer Ng, Kevin Qiu, Erica B. Wang, Shifa Akhtar, Addie Walker, Macartney Welborn, Martin Zaiac, Joan Guitart, Aamir M. Qureshi, Youn H. Kim, Michael S. Khodadoust, Naiem T. Issa, Jaehyuk Choi

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Immune repertoire profiling uncovers pervasive T-cell clonal expansions in benign prostatic hyperplasia
Anna S. Pollack, … , James D. Brooks, Jonathan R. Pollack
Anna S. Pollack, … , James D. Brooks, Jonathan R. Pollack
Published April 3, 2025
Citation Information: J Clin Invest. 2025. https://doi.org/10.1172/JCI186939.
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Immune repertoire profiling uncovers pervasive T-cell clonal expansions in benign prostatic hyperplasia

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Abstract

Authors

Anna S. Pollack, Christian A. Kunder, Chandler C. Ho, Josephine Chou, Andrew J. Pollack, Rachel L. P. Geisick, Bing M. Zhang, Robert B. West, James D. Brooks, Jonathan R. Pollack

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Safety and efficacy of pharmacological inhibition of ketohexokinase in hereditary fructose intolerance
Evi J.C. Koene, … , Patrick Schrauwen, Martijn C.G.J. Brouwers
Evi J.C. Koene, … , Patrick Schrauwen, Martijn C.G.J. Brouwers
Published February 11, 2025
Citation Information: J Clin Invest. 2025. https://doi.org/10.1172/JCI187376.
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Safety and efficacy of pharmacological inhibition of ketohexokinase in hereditary fructose intolerance

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Abstract

Authors

Evi J.C. Koene, Amée M. Buziau, David Cassiman, Timothy M. Cox, Judith Bons, Jean L. J. M. Scheijen, Casper G. Schalkwijk, Steven J.R. Meex, Aditi R. Saxena, William P. Esler, Vera B. Schrauwen-Hinderling, Patrick Schrauwen, Martijn C.G.J. Brouwers

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Passive transfer of patient-derived anti-nephrin autoantibodies causes a podocytopathy with minimal change lesions
Felicitas E. Hengel, … , Tobias B. Huber, Nicola M. Tomas
Felicitas E. Hengel, … , Tobias B. Huber, Nicola M. Tomas
Published January 16, 2025
Citation Information: J Clin Invest. 2025. https://doi.org/10.1172/JCI186769.
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Passive transfer of patient-derived anti-nephrin autoantibodies causes a podocytopathy with minimal change lesions

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Abstract

Authors

Felicitas E. Hengel, Silke Dehde, Oliver Kretz, Jonas Engesser, Tom Zimmermann, Tobias B. Huber, Nicola M. Tomas

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Serum cAMP levels are increased in patients with asthma
Steven S. An, … , Sally Wenzel, Reynold A. Panettieri, Jr.
Steven S. An, … , Sally Wenzel, Reynold A. Panettieri, Jr.
Published January 7, 2025
Citation Information: J Clin Invest. 2025. https://doi.org/10.1172/JCI186937.
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Serum cAMP levels are increased in patients with asthma

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Abstract

Authors

Steven S. An, Gaoyuan Cao, Kwangmi Ahn, Jordan Lee, Dae Young Jung, Loren Denlinger, John Fahy, Elliot Israel, Wendy Moore, Brenda Phillips, David Mauger, Sally Wenzel, Reynold A. Panettieri, Jr.

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Long COVID is associated with lower percentages of mature, cytotoxic NK cell phenotypes
Tasha Tsao, … , Oscar A. Aguilar, Timothy J. Henrich
Tasha Tsao, … , Oscar A. Aguilar, Timothy J. Henrich
Published December 17, 2024
Citation Information: J Clin Invest. 2024. https://doi.org/10.1172/JCI188182.
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Long COVID is associated with lower percentages of mature, cytotoxic NK cell phenotypes

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Abstract

Authors

Tasha Tsao, Amanda M. Buck, Lilian Grimbert, Brian H. LaFranchi, Belen Altamirano Poblano, Emily A. Fehrman, Thomas Dalhuisen, Priscilla Y. Hsue, J. Daniel Kelly, Jeffrey N. Martin, Steven G. Deeks, Peter W. Hunt, Michael J. Peluso, Oscar A. Aguilar, Timothy J. Henrich

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A deep intronic mutation causes RAD50 deficiency through an unusual mechanism of distant exon activation
Kristine Bousset, … , Franco Pagani, Thilo Dörk
Kristine Bousset, … , Franco Pagani, Thilo Dörk
Published December 12, 2024
Citation Information: J Clin Invest. 2024. https://doi.org/10.1172/JCI178528.
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A deep intronic mutation causes RAD50 deficiency through an unusual mechanism of distant exon activation

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Abstract

Authors

Kristine Bousset, Stefano Donega, Najim Ameziane, Tabea Fleischhammer, Dhanya Ramachandran, Miriam Poley-Gil, Detlev Schindler, Ingrid M. van de Laar, Franco Pagani, Thilo Dörk

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Therapeutic hypoxia for mitochondrial disease via enhancement of hemoglobin affinity and inhibition of HIF-2α
Hong Wang, … , Fumito Ichinose, Vamsi K. Mootha
Hong Wang, … , Fumito Ichinose, Vamsi K. Mootha
Published December 2, 2024
Citation Information: J Clin Invest. 2024;134(23):e185569. https://doi.org/10.1172/JCI185569.
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Therapeutic hypoxia for mitochondrial disease via enhancement of hemoglobin affinity and inhibition of HIF-2α

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Abstract

Authors

Hong Wang, Maria Miranda, Eizo Marutani, Paul Lichtenegger, Gregory R. Wojtkiewicz, Fumito Ichinose, Vamsi K. Mootha

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Xylazine induces dopamine release and augments the effects of fentanyl
Joseph R. Trinko, … , Jane R. Taylor, Ralph J. DiLeone
Joseph R. Trinko, … , Jane R. Taylor, Ralph J. DiLeone
Published November 15, 2024
Citation Information: J Clin Invest. 2024;134(22):e183354. https://doi.org/10.1172/JCI183354.
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Xylazine induces dopamine release and augments the effects of fentanyl

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Abstract

Authors

Joseph R. Trinko, Ethan Foscue, Edward M. Kong, Aakash Basu, Anouk M. Corstens, Summer L. Thompson, Alfred P. Kaye, Jane R. Taylor, Ralph J. DiLeone

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Complement-producing maternal microchimeric cells override infection susceptibility in complement-deficient murine offspring
Giang Pham, … , David B. Haslam, Sing Sing Way
Giang Pham, … , David B. Haslam, Sing Sing Way
Published November 14, 2024
Citation Information: J Clin Invest. 2024. https://doi.org/10.1172/JCI187001.
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Complement-producing maternal microchimeric cells override infection susceptibility in complement-deficient murine offspring

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Abstract

Authors

Giang Pham, Raymond E. Diep, Lucien H. Turner, David B. Haslam, Sing Sing Way

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