Cellular profiling identifies targetable T cell phenotypes in lymphocytic variant hypereosinophilic syndrome
Kristy Tefft, … , Brett King, Jaehyuk Choi
Kristy Tefft, … , Brett King, Jaehyuk Choi
Published November 3, 2025
Citation Information: J Clin Invest. 2025;135(21):e190853. https://doi.org/10.1172/JCI190853.
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Research Letter Dermatology Immunology

Cellular profiling identifies targetable T cell phenotypes in lymphocytic variant hypereosinophilic syndrome

Abstract

Authors

Kristy Tefft, Amy Wang, Zachary Z. Reinstein, Yue Zhang, Arundhati Pillai, Sunghee Hwang, Spencer Ng, Raymond J. Cho, Jeffrey B. Cheng, Fei Li Kuang, Brett King, Jaehyuk Choi

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Figure 1

CD3–CD4+ lymphocytes are unique Th2-like cells and express targetable surface markers and cytokines.

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CD3–CD4+ lymphocytes are unique Th2-like cells and express targetable su...
(A) Images of patients 3 and 4. (B) UMAPs of CD4-gated cells aggregated from all samples (n = 6) grouped/colored as indicated. Reg/mem, regulatory/memory. (C) Top 5 clonotypes per sample by cell number. (D) Volcano plot of differentially expressed genes between LHES-associated CD3–CD4+ versus atlas Th2 memory-like cells (Padj < 0.05). (E) Heatmap of SCENIC regulons of naive CD4+ cells and CD3–CD4+ clusters from patients with LHES, atlas Th2 memory-like cells. (F) CellChat analysis among CD3–CD4+ T cells. (G) Absolute blood CD3–CD4+ T cell count in patient 4. (H) Patient 3 clinical course timeline; CTNNB1/STAT3 variant maps. Bar chart of posttreatment variant prevalence confirmed with amplicon DNA sequencing.