In order to protect the body from viruses and cancer, T cells must perform multiple functions, a feature that is often lost during chronic infection. Jonathan Schneck and colleagues examined the molecular mechanisms that maintain T cell polyfunction...
Published December 2, 2013

Damage to the glomerulus, which mediates the kidney's filtering function, causes plasma protein to spill into the urine, a sign of kidney failure and cardiovascular disease. Calcium influx into the podocytes, the cells that form the filtration b...
Published November 15, 2013

Results from early-phase clinical trials have indicated that recombinant adeno-associated viruses (rAAV) could potentially be used for gene therapy. In each trial, however, patients have developed T cell-mediated immune responses that may interfere ...
Published November 15, 2013

Researchers identify cellular mechanisms regulating cancer cell immunogenicity.
Published October 8, 2013

Researchers characterize antibodies that block H5N1 influenza viral transmission
Published September 3, 2013

Lindsey May and colleagues at the National Institute for Deafness and Other Communication Disorders examined how the hair cells of the inner ear respond to stress.
Published July 25, 2013

In this episode of Author's Take, Takeshi Yoneshiro and Masayuki Saito discuss their recent study in which subjects exposed subjects to a daily cold stimulus for 6 weeks had increased BAT activation and reduced overall fat mass.
Published July 15, 2013

Atrial natriuretic peptide is negatively regulated by microRNA-425
Published July 15, 2013

Gene transfer therapy for Sickle cell disease
Published July 1, 2013

Tsonwin Hai and colleagues discuss how the transcription factor ATF3 acts as a key regulator of the host immune response to cancer.
Published June 10, 2013