Modified bacteria keep mice lean: Forbes, Popular Science, Live Science all have features on “Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity” by Zhongyi Chen and Lilu Guo and colleagues.
Understanding Rothmund-Thompson syndrome: The Herald Sun reports on “The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis” by Monique F. Smeets, Elisabetta DeLuca and colleagues.
Dystonia mouse model does the twist: Nature World News covers “TorsinA hypofunction causes abnormal twisting movements and sensorimotor circuit neurodegeneration ” by Cun-Chi Liang et al. Don’t miss the accompanying Commentary, "Twisting mice move the dystonia field forward” by Åsa Petersén and Deniz Kirik
Metabolic disorders, including obesity, diabetes, and cardiovascular disease, are widespread in Westernized nations. Gut microbiota composition is a contributing factor to the susceptibility of an individual to the development of these disorders; therefore, altering a person’s microbiota may ameliorate disease. One potential microbiome-altering strategy is the incorporation of modified bacteria that express therapeutic factors into the gut microbiota. For example,
Zhongyi Chen, Lilu Guo, Yongqin Zhang, Rosemary L. Walzem, Julie S. Pendergast, Richard L. Printz, Lindsey C. Morris, Elena Matafonova, Xavier Stien, Li Kang, Denis Coulon, Owen P. McGuinness, Kevin D. Niswender, Sean S. Davies
Mutations within the gene encoding the DNA helicase RECQL4 underlie the autosomal recessive cancer-predisposition disorder Rothmund-Thomson syndrome, though it is unclear how these mutations lead to disease. Here, we demonstrated that somatic deletion of
Monique F. Smeets, Elisabetta DeLuca, Meaghan Wall, Julie M. Quach, Alistair M. Chalk, Andrew J. Deans, Jörg Heierhorst, Louise E. Purton, David J. Izon, Carl R. Walkley
Lack of a preclinical model of primary dystonia that exhibits dystonic-like twisting movements has stymied identification of the cellular and molecular underpinnings of the disease. The classical familial form of primary dystonia is caused by the DYT1 (ΔE) mutation in
Chun-Chi Liang, Lauren M. Tanabe, Stephanie Jou, Frank Chi, William T. Dauer
A common form of the hyperkinetic movement disorder dystonia is caused by mutations in the gene
Åsa Petersén, Deniz Kirik