Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Comments for:

The several Cs of translational clinical research
David G. Nathan
David G. Nathan
Published April 1, 2005
Citation Information: J Clin Invest. 2005;115(4):795-797. https://doi.org/10.1172/JCI24753.
View: Text | PDF
Personal perspective

The several Cs of translational clinical research

  • Text
  • PDF
Abstract

Perhaps because I am a veteran of the “good old days” (they were really quite bad), young physicians who hope to become clinical investigators often ask me how they might establish their careers. Many are more than a little worried about their futures and often have trouble envisioning a career path that is financially secure for themselves and their families. The grumbling of clinical investigators a few years their senior enhances their angst. So I try to encourage these young physicians because I know the great intellectual (if not monetary) rewards of the field and because I know that the future of medicine absolutely depends on clinical investigators. The following is what I try to say to them.

Authors

David G. Nathan

×

‘Ps’ accompanying ‘Cs’

Submitter: Pramod K. Garg | pgarg10@hotmail.com

All India Institute of Medical Sciences

Published May 5, 2005

I read with great interest the commentary on ‘Patient Oriented Translational Clinical Investigators’ by David G Nathan in the April issue of the journal. Congratulations to him on an excellent piece and in giving credence to people who occupy the middle ground between basic scientists and clinicians. It sums up effectively many things – the dilemma a POTCI faces while starting a career, the conflict a POTCI confronts with between clinical enthusiasm and basic science rigor, the fine balancing act in the tug of war between family and career, and the fear of failure that looms large over a POTCI’s head.
There are of course many ‘Ps’ to keep company with the ‘Cs’: the problems a prospective POTCI faces in pursuit of scientific truth, the paucity of funds for research (and for family), the saga of publish or perish, the perils of failure, and peer pressure. But in the end, it is his passion and perseverance that prevails for him to reach the pinnacle of success.

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts