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iRHOM2 takes control of rheumatoid arthritis
Stefan F. Lichtenthaler
Stefan F. Lichtenthaler
Published January 25, 2013
Citation Information: J Clin Invest. 2013;123(2):560-562. https://doi.org/10.1172/JCI67548.
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Commentary

iRHOM2 takes control of rheumatoid arthritis

Abstract

The cytokine TNF-α is a major drug target for rheumatoid arthritis, an inflammatory joint disorder. An alternative approach is to target the protease TNF-α convertase (TACE), which releases TNF-α from cells. However, because TACE cleaves other proteins involved in development and cancer, a tissue-specific inhibition of TACE in immune cells appears mandatory. In this issue of the JCI, Issuree et al. report that iRHOM2 is a TACE activator in immune cells. Loss of iRHOM2 largely protects mice from inflammatory arthritis, making iRHOM2 a potential drug target for this condition.

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Stefan F. Lichtenthaler

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