The cytokine TNF-α is a major drug target for rheumatoid arthritis, an
inflammatory joint disorder. An alternative approach is to target the protease
TNF-α convertase (TACE), which releases TNF-α from cells.
However, because TACE cleaves other proteins involved in development and cancer, a
tissue-specific inhibition of TACE in immune cells appears mandatory. In this issue
Stefan F. Lichtenthaler
Control of TACE maturation by iRHOM1 and iRHOM2.