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Redox redux: protecting the ischemic myocardium
Oded N. Spindel, Bradford C. Berk
Oded N. Spindel, Bradford C. Berk
Published December 27, 2011
Citation Information: J Clin Invest. 2012;122(1):30-32. https://doi.org/10.1172/JCI61467.
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Commentary

Redox redux: protecting the ischemic myocardium

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Abstract

Cardiac ischemia-reperfusion (I-R) injury occurs upon prompt restoration of blood flow to the ischemic myocardium after an acute myocardial infarction. Interestingly, many of the features of I-R injury are related to impaired mitochondrial signaling and mitochondrial dysfunction. Restoring cardiac energy bioavailability and reduction-oxidation (redox) signaling are therefore important in recovery after I-R injury. In this issue of the JCI, Yoshioka and colleagues describe an important and unexpected role for thioredoxin-interacting protein (TXNIP) in the control of mitochondrial respiration and cell energy metabolism. Their findings could open the door for development of TXNIP-targeted therapeutic approaches for the treatment of cardiac I-R injury.

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Oded N. Spindel, Bradford C. Berk

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